Applications of Cyclodextrins (CDs)  

As one new kind of pharmaceutical  excipient  and food additive, CDs is widely applied in pharmaceutical, food and cosmetics industries.It acts as stabilizer, emulsion ，antioxidant，damp-proofer，rot-proofer, quality-improver, deodorant, odor and taste regulator.

 

◆Regarding to  the General usage of Cyclodextrins, The international Cyclodextrin Association sums up the function as the following:

 

1)Protection of materials against oxidation and UV-degradation

during storage or processing.

2)Stabilization of flavors and spices.

3)Masking of bitterness and unpleasant odor of food and drug.

4)Conversion of liquid materials to dry form.

5)Improve of solubility of materials with low solubility in water.

6)Emulsification of hydrocarbons, steroids, fats, and fatty acids.

7)Controlled release of drugs and flavors.

8)Catalyst for chemical reaction.

9)Constrained medium for chemical synthesis.  

◆     CDs in Pharmaceutical industry applications:

As a result of their molecular structure and shape, it posses a unique ability to act as molecular containers by entrapping guest molecules in their internal cavity. The resulting inclusion complexes offer a number of potential advantages in pharmaceutical formulations

  For Improving  drug’s stability;

For preventing from drug’s oxidation and decomposing;

For increasing  drug’s solubility and bioavailability;

For eliminating  drug’s toxicity;

For eliminating drug’s odor smell or unpleasant smell or taste;

For solidifying  drug’s from liquid form to solid form;

For increasing  drug’s target-direction character;

For controlling  drug’s releasing speed.

 

◆   CDs in Food industry or health care food  field  applications

 CD can entrap guest molecules in their internal cavity, The resulting inclusion complexes offer the advantages in food industry such as

For  improving stability of food or active ingredients, and preventing from oxidation, light, heat, and volatility, and protecting pigments

For conversing food from liquid form to solid form;

For eliminating bad smell or taste of food;

For Improving the emulsification and foam forming;

For forming solid wine or juice powder;

For preventing from food deliquescence or being damp;

For preventing from food being rot;

For Improving the quality of food for long time storage;

For being the assistant material in food industry.

CDs Functions in food and Health care products

The list of products can use CDs 

improving stability of food or active ingredients, and preventing from oxidation by light, heat, and volatility, and protecting pigments

Volatile oils type

Onion oil, shallot oil, garlic oil, ginger oil, sesame seed oil, sage oil, lemon oil, mushness oil, dill oil,wormwood oil, mustard oil, rosemary oil, cardamom oil, laurel leaf oil, basil oil peppermint oil, anise oil, cinnamon oil, thyme oil, carrot oil, coriander oil, angelica oil, marjoram oil,billberry seed oil,orange oil, vanillic oil, propenyl mustard oil, vitex negundo oil, capsicum paste oil, bramble oil, chamomile oil etc.

Volatile aldehydes

Volatile Aldols etc.

Citral, citronellal, d-lemonene, musktone,laurone, lauraldehyde, undecyl decanal, nonaldehyde, anesole, camphor, coriandercol, ethylene, Vitamin E etc.

Coloring matters

Or food pigments

Abietine,Cathamin,carotin, karaya pigment, hebiscetin, armaranth red, riboflavin,kermes red, hesperetin, Monascus pigment,chlorophyl and quinones, porphyrins, benzoquinones, ketones, B-anthocyanidin, and flavones pigments.

Nutritional ingredients or herbs extracts 

Amino acids and Vitamines , DHA and EPA,Co-Q10 etc.

Improving the quality of food for long time storage as assistant materials in food industry

Candy, chocolate, maltose, coffee, biscuit, cake,pasty, spicy powder, instant food, instant tea, soy, mayonnaise,susage, bamboo-tin, Japanese fermented soybean, hydrolyzed  protein solutions,hydrolyzed cheese solutions, bean-curd coagulant, substitute of intestines coasting for sausage, Tangeretin, nut powder, melon seed powder, syrup powder, juice powder, mayonnaise powder, levulose powder, chewing gum etc.

CDs serve as preservatives

Cds can  prolong the valid time of Sorbic acid,

Sodium Dehydroacetate, Benzoic Acid, Sodium benzoate, Iodid, -tol type.

Eliminating bad smell or taste of food

Fish, mutton, soy product, soy protein, lecithin, butter, cheese, silk-worm protein,yeast powder or paste, asparagus, tomato paste,radish,galic products, orange juice, grape juice, other froot juice,

Stevia leaf, Saccharine, protein-candy, Glycyrrhizin Acid,crusted-rice etc.

Improving the emulsification and foam forming

High-oil beverages, mayonnaise, seasoning oil, ice cream, coffee beverage, lipin food, frozen food, protein powder, surface-active agent for sugar and starch sugar products etc.

Forming solid wine or juice powder

Extempore  Martini- wine- powder,  Whisky-wine-powder, champagne powder, other wine powder, powdered food oil, garlic powder, shallot oil powder, sesame seed oil powder etc.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Applications Method and amount

 

1.Applications Method

When CDs is applied for production, It is necessary to use CD to include the guest active ingredient to make CD inclusion complex at first, then, mix the CD inclusion complex with other required substance to make ideal products, the brief of formulate CD inclusion complex methods for reference as follows:

◇    Saturated Solution Method

A.      Direct Method: By putting guest compound or ingredient into saturated CD solution slowly, Stirring the solution for 30 minutes for reaction, then let the solution deposit, filter the solution, washing, and drying, the CD inclusion complex is made.

B.      Solvent Method: By dissolve the difficult been dissolved guest substance such as fatty acid or oil with acetone or ethanol or other solvent, and then employ the Direct method to work further.

◇    Grinding Method: by putting 2-5 times of water into CD and mix guest substance together ( if necessary, dissolve guest substance into solvent to make solution in advance), using ball miller other other miller to mix the solution completely to form paste form, then by heating drying, washing by solvent to get stable CD inclusion complex subsequently.

◇   Frozen Drying Method: if powder CD inclusion complex is needed, and CD inclusion complex is water-soluble, and easily color changed and decomposed by heating drying, then using Frozen drying method to eliminate solvent and form powder. By this method the CD inclusion complex keeps good water-solubility.

2.       Application Quantity of CD: The quantity of consumption of CD depends on the guest’s molecular size  and polarity. in general way, CD to guest’s mol quantity is 1:1  to 1:2 or more, the specific ratio should be adjusted according to different processing procedure and the characters of guest substance to suitable ratio.

 

Note: The above mentioned CD consumption is Beta-CD, other type of CD will be adjusted properly.